5 years Strategic plan for HIV prevention in Swaziland

Angola essays

Angola essays Angola is a country on the southwest coast of Africa. Its official name is the Republic of Angola. The Congo River and Congo (Kinshasa) separate it from the rest of the country. Most of Angola's people live in rural areas and work on farms. Angola produces a variety of crops, including bananas, coffee, corn, sugar cane, and a starchy root called cassava. Angola also has many natural resources, including diamonds, iron ore, and petroleum. Luanda, the capital and largest city, is a major African seaport. A president is the most powerful official in Angola's government. The National assembly, the country's legislature, makes the laws. The people of Angola elect both the president and the National Assembly. The people in Angola are black Africans. The blacks belong to several ethnic groups, including the Ovimbundu, the Mbundu, the Kongo, and the Luanda-Chokwe. Before the nation became independent, more than 400,000 Europeans and mestizos (people of mixed black African and white ancestry) lived in Angola. Most Europeans fled during a civil war that began after the country achieved independence. The people who live in Angola's rural areas work as farmers and herders, and many raise just enough food for their own use. Most black Angolans speak a language that belongs to the Bantu language group. Europeans, mestizos, and some blacks speak Portuguese, the official language. About 90 percent of the people are Christians, mostly Roman Catholics. Others practice religions based on the worship of ancestors and spirits. Angola forms part of the large inland plateau of southern Africa. The country consists chiefly of hilly grasslands, but a rocky desert covers the south. Temperatures average about 70 F in January and about 60 F in June. From 40 to 60 inches of rain falls annually on the northern coast and in most of the interior. Only ...

The decline of US hegemonic power Essay Example | Topics and Well Written Essays - 1000 words

The decline of US hegemonic power - Essay Example However, this theory has been under strong criticism from emerging theories such the power transition theory which views parity among a great nation which is a challenger and the dominant nation as the cause of war rather than peace and stability. According to this theory, peace can only be achieved when a greater power surpasses the dominant nation (D’Anieri, 2009). Since World War II, the US has been the dominant or hegemonic power owing to its enormous wealth and influence in the global scene. However, according to Witkopf (1997) hegemonic periods last approximately 60-90 years. So could America be on the decline owing to the fact that it has been a hegemonic power for over 60yrs? This is what this paper will try to find out. In doing so, it will utilize the levels of analysis in international system to explain the decline of US hegemonic power. These levels of analysis include the individual, state-level and system-level analysis but first, the power transition theory will be expounded further in order to understand how the international system works as opposed to the balance of power theory and levels of analysis. ... The balance of power theory would tell us that the system would be stable as long as the strong nations are at par or are satisfied with the system. The dominant nation influences how the international system operates and makes the rules of the game (D’Anieri, 2009). For example, the US determines the rules in the system and other nations follow. However, emerging nations may feel left out of the system despite having the capability to be involved in making rules and defending their interests. As such, they challenge the status quo to get a place in running the system. This leads to war as the strong nations defend their status and stability is only achieved when parity is achieved (Wittkopf, 1997). For power transition theorists, stability is impossible when nations are at parity, meaning they have capacity and resources to fight each other. If the challenger nation which is a great power does not have the capacity to fight the dominant nation, it cannot wage war against it u ntil such a time it will have equal power. If it gains more power than the dominant nation, then it has no business waging war against it since it has already acquired the superpower status. The danger is therefore when the transition is taking place. War is inevitable to determine who governs the international system (Tammen, 2000). Since the nations get weary after a power transition, they remain at peace for some time before thinking of engaging in conflict. The status gained after the transition does not last for long as evidenced by previous wars. Rome, Britain and Mongols were once superpowers but their power and dominance declined and US attained the status (Hamraie, 2013). The US is no exception and has

GOOGLE GLASS Coursework Example | Topics and Well Written Essays - 1500 words

GOOGLE GLASS - Coursework Example Businesses are now conducted online. The target of the distribution plan should be based on the online platforms (Shaw & Onkvisit, 2009). Individuals who have similar or common interest can be identified in the online platform. The targeted group of consumers should be selected in a way that the marketing strategy satisfies a wide range of the needs of the firm and the consumers. The client groups are targeted and identified using a similar interest element. The targeted group should be selected in terms of individuals with similar needs. It is easier to identify such clients, because the lifestyle of the people, demography, and ability of market growth. This is a transparent prove that Google glass has a potential market. Google glass has grown very fast in terms of attracting customers and quality due to their many inventions. They have able to compete with big companies. They manage this due to the strong brand affection they have. They invest more in brand loyalty than marketing making them to be on top of other. They work on how to make the customers prefer by using technology to create different makes of their devices to serve a large population. Google glasses are a combination of vital factors and elements that are required by an organization in order to accomplish a certain objective that marks their achievement. Hospitals require the tool to meet the demands of its clients. Numerous success factors and concepts, and ideas are being witnessed in the stream of the papers, media and other advertisement platforms, but there is still a little evidence tends to prove that the success factors can significantly assist an organization to boosts and propel its performance (Shaw & Onkvisit, 2009). Firms and organizations are trying to explore numerous options so that they may achieve success by attaining their client’s expectations. It is with the idea of innovating Google glass that there is a realization that it can meet the

Political Critiques of Articles Essay Example | Topics and Well Written Essays - 2500 words

Political Critiques of Articles - Essay Example It got me thinking that if I got this heart wrenching feeling about this piece of story that has attracted great publicity between the two countries, how do the mother, father, siblings, guardians, family and friends in general feel about this? This brings to question what would have gone wrong between the times of his conception till his puberty. Could it be bad parenting? Stress from home or school? Peer pressure? Or adventure? How and where did he get the drugs from? Not that I am naive but shouldn’t it bother us that children below the age of sixteen can easily access this drugs? The teenager is set to be released after being in custody from the 4th of October. The Australian government through its foreign minister said that securing his release was the number one priority, not that I disagree but shouldn’t the number one priority also be to find these people who sell these drugs to the minors? There is a record of people who have been caught with drugs in Bali, and not just ant people, but specifically Australians. Schapelle Corby an Australian was arrested in 2004 trying to smuggle marijuana into Bali using the case of her boogie board as the get through. She had 4.1 kilograms of marijuana. Her sentence wasn’t light as that of the fourteen year old boy, she is serving a 20year jail term. A year later, nine Australians were arrested with attempting to export eight kilograms of heroin through the same airport. They later came to be known as the â€Å"Bali nine†. Apparently, they are in jail. Doesn’t this bother the Australian government? It has happened three times which are on record. This clearly shows that it is a habit. What is the government doing about it? Article 2 Syria has become a bloody zone with the ongoing clashes in several cities resulting to many people being dead. The reason behind the terror that has gripped the region is simple, all Syria has to do is accept monitors, a demand being put across by the Ara b league and if they deny they will face sanctions. The deadline has passed without Syria agreeing to those terms. President Bashar Assad’s government had been given a simple task of accepting and signing a protocol for an observer that would oversee a peace plan but no, they had to keep quiet on this issue and let fierce clashes erupt taking away innocent lives. Peace is what most leaders advocate for thus winning with a landslide that it is a good thing. Why does Bashar’s government agree with the Arab foreign ministers and take this anguish away from the people of Syria? Syria has already been suspended from the 22-member block, which is quite humiliating. Accusations fly from either party with the Syrian government making allegations that the Arab league is acting like a tool for the United States and other western governments. The media has gone ahead and said that the threat of the Arab sanctions is an unprecedented procedure that affects the Syrian people. While all this politics is going on they don’t see that innocent souls are dying, they are paying for the sins of others who continue living in their comfortable and beautiful homes. Since the eruptions, 3500 people have since died making it one of the bloodiest uprisings in the Arab world. The restriction of journalists in Syria clearly shows that the Syrian government is on the wrong. If it has nothing to hide then why wouldn’t it allow media coverage? There are numerous reports of human rights violation.

Working hard is always rewarded

Working hard is always rewarded Persuasive Essay: Success is due to hard work not luck Success has just as many faces as any other possible theme, depending on the society in which it is measured, and the character of the person who measures it. Wrongfully, many people confuse success is only associated with wealth: they assume that a persons triumph can be concluded from the expensiveness of his or her watch, car, or house. But will they be successful just because they are rich? Albert Schweitzer famously once said Success is not the key to happiness. Happiness is the key to success. If you love what you are doing, you will be successful. For its only when you find satisfaction with what youre doing and dont dread facing every new day when your task has to be embarked upon, that you are really successful. Therefore, success should be not only being measured with wealth but also with happiness. Since time immemorial everybody has been striving for success which could fulfill many dreams. It is generally accepted that success is not easy to achieve and depended on a lot of factors, such as hard work, good luck, health condition or even the once-in-a-lifetime chance. Today, people are pushing, but in vain, for a shortcut to their desired successes. Through my lens, I have faith that a grand success primarily comes from hard work, and also from good luck partially. In this train of thought, I would say that I agree that success is the main consequence of hard work. Working hard is always rewarded- earning a lot of money or gaining personal achievements, just like when Im doing this essay, after so much effort being put in, it feels extremely rewarding to know that I have finally accomplished it. I believe that the vast majority of people, who have highly-paid jobs, have worked to death in order to fulfill their goals. It is common sight to see them having to work overtime in order to achieve what they set out for. Parents, teachers and friends promote the idea of working hard- they usually say Learn harder if you want to live better. In my opinion, when people are successful, they can easily measure the quality of their work. For instance, when Albert Einstein won the Nobel Prize for Physics, he has not succeeded because of his luck. All of the inventions and theories were a result of his persistence, patience and hard work. What is more, an inspirational saying by the American poetess Marianne Moore goes Victory wont come to me unless I go to it, which manifestly indicates that the key to success is the hard work we have to make. Although others may argue that hard work does not guarantee success, it can be seen that many people of all professions have worked through the ranks to become what they are right now. They had worked hard for many years and ultimately they got success in their life and are currently enjoying their fruits of labour. Thus, it can be seen that hard work paves our way to success. Unlike luck, you can create success by working hard and not wait for success to befall. What makes Tiger Woods great? What made Berkshire Hathaway Chairman Warren Buffett the worlds premier investor? You think you know: Each was a natural who came into the world with a gift for doing exactly what he ended up doing. As Buffett told Fortune magazine not long ago, he was wired at birth to allocate capital. Its a one-in-a-million thing. Youve got it or you dont. Well, folks, its not so simple. For one thing, you do not possess a natural gift for a certain job, because targeted natural gifts dont exist. You are not a born CEO or investor or chess grandmaster. You will achieve greatness only through an enormous amount of hard work over many years, and not just any hard work, but work of a particular type thats demanding and painful. Buffett, for instance, is famed for his discipline and the hours he spends studying financial statements of potential investment targets. Also, Winston Church ill, one of the 20th centurys greatest orators, practiced his speeches compulsively. Vladimir Horowitz supposedly said, If I dont practice for a day, I know it. If I dont practice for two days, my wife knows it. If I dont practice for three days, the world knows it. That shows how much hard work and sheer determination he had to put in order to achieve his status. However, others may argue that luck is needed as you need the talent to begin with. The good news is that your lack of a natural gift is irrelevant talent has little or nothing to do with greatness. A perfect example is basketball legend Michael Jordan. Had Jordan possessed some mammoth natural gift specifically for basketball, it seems unlikely hed have been cut from his high school team. He gained his legendary status via brutal discipline of his daily routines. Through hard work, you can make yourself into any number of things, and you can even make yourself great. For most people, work is hard enough without pushing e ven harder. Those extra steps are so difficult and painful they almost never get done. Thats the way it must be. If success were easy, it wouldnt be rare. All of us have the potential to be successful by giving full expression to our strengths with sincere effort. You need to defined your goals and work towards it. You have to be consistent in what you do and putting in effort till you achieve your goals instead of relying on luck which will not guarantee you success, especially when it is random.

The Untouchables: Mise-en-scene Analysis :: Film Movie

The Untouchables: Mise-En-Scene Analysis   Ã‚  Ã‚  Ã‚  Ã‚  Elliot Ness, a treasury agent, has been trying to stop alcohol from being smuggled into the United States. He feels that the key to putting an end to the alcohol distribution is to put gangster, Al Capone, behind bars. But there is a small problem, Ness can't seem to be able to link the incoming alcohol, or any other crime to Capone. Until, Oscar Wallace, the uptight, â€Å" dorky†, government official, entered the picture to help Ness fight his battle for prohibition, and ultimately, against Capone. Wallace discovered that Capone hasn't paid his taxes for several years, but the only way to prove it is to get to Capone's book keeper. Ness discovers that the book keeper will be going to the train station, so he along with colleague George Stone intend to be there to pick him up when he arrives. The scene starts in the train station. The setting is the main lobby. The floors, pillars, and stairs are of a light gray color. There is a clock that is directly above the big, dark, wooden doors that are continuously reverted back to during the scene. The costumes of the main characters in this scene are the same as throughout the movie. Ness wears a light gray colored suit, hat, trench coat and tie. Stone is wearing a little darker colored, more casual, clothing with a tie and light colored hat. Capones men were dressed similarly with trench coats and hats of light colors. Also, the innocent bystanders in this scene are the sailors in their suits, the woman, with the baby in her innocent raggy clothes, and all the other people in the scene who look as though they might be Capones men. The lighting in this scene is a little bit dull, but gets darker when Capone shoots his gun at certain points of the scene.   Ã‚  Ã‚  Ã‚  Ã‚  The figure movement and expressions in this scene are normally paced, excluding the woman desperately struggling to get her baby carriage up the stairs, until the gunfire starts. The scene turns into slow motion and panic arises as the shooting begins and the baby carriage is released and slowly starts descending down the stairs. The mothers face is panicked and you can see her mouthing the words "My Baby". Then you see the innocent face of the baby and then the carriage plummeting to the bottom of the stairs. The expressions on Capones men are uncaring and crazy looking where as the expressions of the cops were determined looking. Also, the book keepers face is very frightened.

The Risks Of Cardiovascular Disease Health And Social Care Essay

The Rheos System is the device that can be used to take down blood force per unit area in patients who have immune high blood pressure ; the mechanism being stimulation of the carotid baroreceptors. It is unknown if there is any interaction between Rheos and conventional pacesetters. ( KARUNARATNE et al, 2010 ) I will besides be speaking about a really recent therapy for hypertensive patients ; nephritic sympathetic denervation ( RSD ) . It uses a state-of-the-art technique, â€Å" transdermal, catheter-based radiofrequency extirpation † . This has been shown to be good in patients with immune hypertension.A ( DOUMAS et al, 2010 ) Sufficient decrease in blood force per unit area can be readily achieved by bring oning unsusceptibility against marks in the RAAS. The mark antigen is a important factor in the effectivity and safety of the vaccinum. The angiotonin II vaccinum: CYT006-AngQb lessenings blood force per unit area in worlds but the consequences nevertheless were non consistent with more frequent dosing. Vaccines which can be used for hypertensive patient are still in the early stages. ( DO et al, 2010 ) High blood pressure has a high prevalence and has a slightly ill-defined definition. ( HASTIE et al, 2010 ) High blood pressure is something that needs to command. It is recommended that at least every five old ages grownups should hold their blood force per unit area checked until the age of 80. Peoples who have a high normal value for their systolic blood force per unit area, for illustration between 130 and139 mm Hg or who have a high normal value for their diastolic blood force per unit area, for illustration between 85 and 89 millimeters Hg ) are recommended to hold their blood force per unit area measured every twelvemonth. ( Brown et al, 2004 ) I will be discoursing some of the new anti hypertensive drug therapies available, the two chief 1s being viz. the carotid baroreceptor stimulation therapy and the nephritic arteria denervation process. Large-scale clinical tests and clinical surveies are presently traveling on with the purpose of specifying the safety of both the intercessions. ( GRASSI et al, 2010 ) This new implantable device which stimulates the carotid baroreceptors ( Rheos device ) activates the carotid baroreflex. This is done electrical stimulation of the carotid fistula wall: electrodes are really implanted on the outside surface of the carotid fistula wall. This is the first new therapy I will be speaking about. ( TOIDOIR et al, 2007 ) Activation of the nephritic sympathetic nervousnesss is a cardinal issue to the pathogenesis of indispensable high blood pressure in patients hence why I have decided to speak about this new approaching nephritic arteria denervation process. ( SYMPLICITY HTN-2 INVESTIGATORS et Al, 2010 ) I am besides traveling to be discoursing a new blood force per unit area vaccinum. The AngQb vaccinum uses an immunisation technique which involves the junction of angiotonin II to atoms which are similar to viruses. In a celebrated stage 2 test published in the Lancet, hypertensive patients were vaccinated with 300 mcgs of the vaccinum. After 14 hebdomads at that place was really a difference of 9.0 ( systolic ) /4.0 ( diastolic ) millimeter Hg. There were besides no serious inauspicious events recognized with the vaccinum disposal. ( GRADMAN et al, 2008 ) I will briefly speak about current medicine for hypertensive patients and eventually reexamine published documents which discuss conformity and attachment to anti hypertensive medicines. Carotid BARORECEPTORS: 1000 words The definition of immune high blood pressure would be the province that some patients face when antihypertensive drugs are non able to take down the blood force per unit area. This is a job that many physicians face at the minute in clinical pattern. ( GRASSI et al, 2010 ) . The chief intent of the arterial baroreflex is to keep the blood force per unit area rather near to a peculiar set point ( this is over a short period of clip. ) It is imperative to minimise blood force per unit area variableness by baroreflex mechanisms. In hypertensive worlds and animate beings, the baroreflex control of bosom rate has been shown to be diminished. ( HEAD et al, 2005 ) Therefore, it would follow on that a good mechanism of blood force per unit area control would be electrical activation of the carotid baroreflex. In the sixtiess and 1970s the carotid baroreflex was modulated as portion of the intervention for immune high blood pressure. The carotid fistula nervousnesss were stimulated inveterate utilizing implanted nervus electrodes and an implantable receiving system. However, t16 T. Reich, J. Tuckman, A.F. Lyon and J.H. Jacobson II, The effects of wireless frequence carotid fistula nervus stimulators in terrible high blood pressure, Surg Forum 18 ( 1967 ) , pp. 174-176.his technique ne'er became established as a possible therapy for high blood pressure. This was due to two chief grounds, one was the development of new pharmacological agents used in the intervention of high blood pressure ( e.g. ACE-Inhibitors ) and secondly because of proficient restrictions of implantable medical devices. ( TOIDOIR et al, 2007 ) More recent observations in inveterate instrumented animate beings have shown that the stimulation of carotid baroreflex can positively influenceA the long-run ordinance of arterial blood force per unit area. ( TOIDOIR et al, 2007 ) The Rheos System is an deep-rooted carotid fistula baroreflex triping system with a pulse generator and bilateral perivascular carotid fistula leads ( CSLs ) .It is has been and is still being evaluated in clinical tests for the intervention of drug-resistant high blood pressure. ( SANCHEZ et al, 2010 ) An of import clinical test was published last twelvemonth in Germany which tested this Rheos device. It looked at 7 work forces and 5 adult females ( an age scope crossing between 43 – 69 old ages ) who all suffered from immune arterial high blood pressure ( intervention resistant ) . Approximately one month before the survey took topographic point a â€Å" bilateral electric baroreflex stimulator † was implanted at the degree of the carotid fistula ; this was the Rheos device. Assorted things were measured including the intra-arterial blood force per unit area, bosom rate, plasma renin, musculus sympathetic nervus activity, cardiac and sympathetic baroreflex sensitiveness and norepinephrine concentrations. ( HEUSSER et al, 2010 ) These measurings were all performed under resting conditions, both with electric baroreflex stimulation and besides without electric baroreflex stimulation. The arterial blood force per unit area was 193 millimeter Hg ( plus or minus 9 ) over 94 ( plus or minus 5 ) millimeter Hg on medicines. The electric baroreflex stimulation reduced systolic blood force per unit area by 32 ( plus or minus10 ) millimeter Hg ( the scope being +7 to -108 mm Hg ; P=0.01 ) . ( HEUSSER et al, 2010 ) My reading would be that this is a really strong P value giving first-class grounds that this Rheos device is good for hypertensive patients. Muscle sympathetic nervus activity decreased rather aggressively when electric stimulation was started. After the lessening, there was an activity addition. However, throughout the existent stimulation period it remained below the baseline degree. Heart rate decreased 4.5 plus or minus 1.5 beats per minute with stimulation ( P & lt ; 0.05 ) . Again the P value here is important beef uping the grounds for Rheos device. The renin concentration in the plasma decreased 20 % plus or minus 8 % ( P & lt ; 0.05 ) . Yet once more here we have another important P value. The electric field stimulation of carotid fistula baroreflex did acutely decreased blood force per unit area in the patients. There were no negative effects on the existent physiological baroreflex ordinance. The response was mediated through sympathetic suppression. ( HEUSSER et al, 2010 ) MORE REVIEWS ON THIS Nephritic ARTERY DENERVATION: 1000 words Renal sympathetic hyperactivity is really associated with high blood force per unit area. Progression of high blood pressure can do chronic kidney disease ( CKD ) and bosom failure. A test was done in 2009 where nephritic sympathetic denervation was tested in patients who suffered from immune high blood pressure. The patients ‘ systolic blood force per unit areas were tantamount to 160 millimeters Hg or even higher ; they were all on 3 or more medicines for their high blood pressure ( this included a diuretic ) to reasonably measure blood force per unit area decrease effectivity every bit good as safety. The survey took on 50 patients who were all from five different European Centres. 5 patients were excluded from the nephritic denervation for anatomical grounds. They all received â€Å" transdermal radiofrequency catheter-based intervention † between the day of the months June 2007 to November 2008. They all besides had subsequent followup to 1 twelvemonth. ( Krum et al , 2009 ) The survey looked at the effectivity of nephritic sympathetic denervation. The primary end points included the blood force per unit areas at one, three, six, nine and twelve months after the process. In patients who had been treated with nephritic sympathetic denervation the baseline mean blood force per unit area was 177/101 millimeter Hg, ( average 4.7 antihypertensive medicines ) . The estimated GFR was 81 mL/min/1.73mA? . After the process the blood force per unit areas were reduced rather well. They were reduced by â€Å" -14/-10, -21/-10, -22/-11, -24/-11, and -27/-17 † millimeter Hg at one, three, six, nine and twelve months, severally. In the five patients who had non been treated, there was a average rise in blood force per unit area. The rises at one, three, six, nine and twelve months were â€Å" +3/-2, +2/+3, +14/+9 † , and +26/+17 mm Hg severally. ( Krum et al, 2009 ) The resultsA from this test were promising ; the catheter-based nephritic denervation caused sustained blood-pressure decrease in patients with immune high blood pressure. The decrease in blood force per unit area was rather significant and was without any serious inauspicious events. It was evaluated that more randomized clinical tests are necessary in order to look into the utility of this process farther. ( Krum et al, 2009 ) Equally good as this survey, another test was done the twelvemonth after ; this test was more big graduated table and was published in the Lancet. The purpose of this test was similar to the last 1 in that, they wanted to measure how effectual the catheter-based nephritic denervation in cut downing blood force per unit area in patients who had treatment-resistant high blood pressure was. The safety of the process was besides to be evaluated. In this randomized test, the patients used were those who had a systolic blood force per unit area of either 160 mmaˆ?Hg or more ( despite taking 3 or more antihypertensive drugs ) at the start of the test. These patients were indiscriminately allocated to hold the nephritic denervation with old intervention or to the other group: to keep old intervention entirely ( command group ) . The ratio for patients holding option 1 compared to option 2 was 1:1. The test included 24 take parting centres.A ( SYMPLICITY HTN-2 INVESTIGATORS et Al, 2010 ) 106 of the 190 patients ( this is tantamount to 56 % of the entire patients ) screened for eligibility were indiscriminately allocated to two different groups. The first group were the patients who were to have nephritic denervation, 52 patients were put here. The 2nd group was the control group, there were 54 patients put here. This happened between the day of the months June 2009 and January 2010. 49 of 52 patients who underwent the nephritic denervation were assessed after 6 months after the start of the test. 51 out of 54 patients who were in the control group were besides assessed after 6 months. In the nephritic denervation group, the blood force per unit areas were reduced by 32/12 mmaˆ?Hg, holding had a baseline of 178/96 mmaˆ?Hg, P & lt ; 0A ·0001. On the other manus, the blood force per unit area measurings in the control group were non different to the baseline blood force per unit areas, alteration of 1/0 mmaˆ?Hg, baseline being 178/97 mmaˆ?Hg. ( SYMPLIC ITY HTN-2 INVESTIGATORS et Al, 2010 ) The differences in both groups in footings of blood force per unit area at 6 months were hence 33/11 mmaˆ?Hg ( p & lt ; 0A ·0001 ) . The P value here is highly important, back uping grounds for this therapy. The happening of any inauspicious events was non different between the two groups. Overall, there were no studies about any serious procedure-related/device-related complications. It was evaluated that catheter-based nephritic denervation can well cut down blood force per unit area in patients with treatment-resistant hypertensive and can be used safely whilst making this. ( SYMPLICITY HTN-2 INVESTIGATORS et Al, 2010 ) REVIEWS ON THIS NEEDED BP VACCINE 500 words In carnal theoretical accounts, inoculation against renin has been shown to be effectual but has resulted in quite fatal autoimmune nephritic disease. Vaccines directed at angiotonin I and II and a section of the angiotonin 1 receptor did cut down blood force per unit area ( BP ) without doing autoimmune disease. In worlds, angiotonin I vaccination did non really cut down BP. ( GRADMAN et al, 2008 ) In the last twosome of old ages at that place has been some new grounds that a new blood force per unit area vaccinum could assist lower blood force per unit area. CYT-006-AngQb is a vaccinum in which a peptide derived from the angiotonin II molecule conjugates to the surface of virus-like atoms. ( PHISITKUL et al, 2009 ) The vaccinum was designed to assist dainty patients who suffered with high blood pressure. The vaccinum has the benefit of holding a comparatively durable consequence and therefore does non necessitate day-to-day dosing in comparing with pharmacological therapies. It was found that in hypertensive rat theoretical accounts, the vaccinum induced angiotensin-II-specific antibodies and decreased systolic blood force per unit area. This seems to be the method of how the vaccinum works. It is basically made up of a peptide which is derived from the Air National Guard II molecule, and this is so conjugated to the surface of virus like atoms. ( PHISITKUL et al, 2009 ) Presently, high blood pressure can be controlled sufficiently with bing drugs such as ACE inhibitors/angiotensin II receptor blockers. However, intervention success is often restricted by patients who do non adhere to intervention. Immunisation against angiotonin II could work out this job. A celebrated survey was published in the Lancet merely over 2 old ages ago and it investigated the efficaciousness and safety of CYT006-AngQb. This is a vaccinum that is based on a virus-like atom ; the vaccinum marks angiotensin II in order to seek and cut down ambulatory blood force per unit area. ( TISSOT et al, 2008 ) The test was a placebo-controlled randomized â€Å" stage IIa † test. It consisted of 72 patients who suffered from mild-to-moderate high blood pressure. They were all were indiscriminately assigned to have injections of one of the undermentioned doses: 100 I?g of CYT006-AngQb, 300 I?g CYT006-AngQb or placebo. There were patients in each of the 3 groups. They were given their dosage at 3 different intervals ( hebdomads 0, 4, and 12 ) . Twenty four hr ambulatory blood force per unit area was measured twice, one time before intervention and so at hebdomad 14.A The reading was as follows: immunization with CYT006-AngQb vaccinum was linked with no serious inauspicious events which was assuring. In peculiar, the 300 I?g dosage decreased blood force per unit area in patients who had mild-to-moderate high blood pressure during the daylight ( chiefly in the early forenoon ) . ( TISSOT et al, 2008 ) This new vaccinum inhibits the renin-angiotensin-aldosterone system ( RAAS ) . This has made many clinicians question whether it is safe suppressing the actions of angiotonin II for several months? Some surveies have argued that suppression of the renin- angiotensin- aldosterone system could be unsafe as the suppression could do salt and volume depletion and hence dangerous hyperkalaemia. a farther of import safety issue would be whether perennial stimulation of the immune system by supporter doses of a peptide could can do autoimmune disease ( SAMUELSSON et al, 2008 ) Although there are many inquiries remain sing efficaciousness and safety, RAAS immunisation represents a really advanced attack to anti hypertensive intervention. ( GRADMAN et, 2008 ) Given the mechanism of the vaccinum CYT-006-AngQb, and the first-class potency of complementing other high blood pressure interventions, success in ongoing stage II tests in patients with high blood pressure would do this therapy a valuable add-on for advisers handling hypertensive patients. ( PHISITKUL et al, 2009 ) Current intervention: 500 words Presently a broad scope of drugs are available for patients who suffer from high blood pressure. The chief 1s include water pills, sympathomimetic receptor adversaries, sympathomimetic receptor agonists, ca impart blockers, ACE inhibitors, Angiotensin II receptor adversaries and aldosterone adversaries. The chief diuretic most normally used in clinical practise isA bendroflumethiazide, which is a thiazide water pill. Other thiazide water pills include: Diuril, Microzide and epitizide. Loop water pills include: butmetanide, ethacrynic acid, Lasix and torsemide. Thiazide like water pills include: Hygroton, Lozal and metolazone. In add-on, there are besides potassium saving water pills which include amiloride, triamterene and Aldactone. Adrenergic receptor adversaries include foremost alpha blockers, secondly beta blockers and eventually assorted alpha and beta blockers. Examples of alpha blockers include Minipress, A Hytrin, Cardura, tolazoline, trimazosin, Vasomax, indoramin and phenoxybenzamine. Some illustrations of beta blockers include: Sectral, Tenormin, bisoprolol, Lopressor, oxprenolol, Visken, propanaolol, sotalol, and Blocadren. Assorted alpha and beta blockers include bucindolol, carvedilol and lebetalol. Alpha blockers tend to be non recommended as first line intervention for high blood pressure. Alpha-2 agonists include Catapres, alpha methyl dopa and guanfacine. Calcium channel adversaries include amlodipine, diltiazem, felodipine, isradipine, lacidipine, lercanidipine, nicardipine, nifedipine, nisoldipine, and Calan. Examples of ACE inhibitors are: Capoten, cilazapril, Vasotec, fisinopril, Prinival, perindopril, quinapril, Altace, and Mavik. There are assorted angiotensin II receptor adversaries including: candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan and Diovan. Finally, aldosterone adversaries include eplerenone and Aldactone. Talk ABOUT DIFFERENT CLASSES AND NICE GUIDELINES. Conformity + attachment to intervention: In footings of conformity to anti hypertensive medicine, there are some rather lurid figures. It has been stated that the bulk of over 1 billion hypertensive patients around the universe really remain with uncontrolled blood force per unit area. Furthermore, among existent hypertensive patients who do have anti hypertensive intervention, at least half of them fail to make presently recommended blood force per unit area marks ( in most states ) . ( GUPTA et al, 2010 ) It has been estimated that about 30 per centum of the grownup population in the United Kingdom are hypertensive, with their blood force per unit areas being over 140/90A millimeters Hg. It is either over 140/90 millimeters Hg or they are on blood force per unit area take downing medication.A Apparently, over half of hypertensives in the United Kingdom are non even on any intervention, and in add-on about half ( possibly even more ) of the people who are on the anti hypertensive intervention have blood force per unit areas over the existent threshold, 140 over 90A millimeters Hg. WHO ( World Health Organization ) estimates that about 50 to 70 % of patients do non take their antihypertensive medicine, and has described poor/non attachment to anti hypertensive medicine as the most important cause of uncontrolled /poorly controlled blood force per unit area. ( MANT et al, 2006 ) A systematic reappraisal was done in 2004 of randomized controlled tests which had looked at attachment to medicine with regard to blood force per unit area control. It was found that in seven of the tests an betterment in attachment to medicine was really associated with a lessening in blood force per unit area. However in a farther seven tests, a lessening in blood force per unit area was achieved even though there had been no betterment in attachment. Although this demonstrates that attachment to medicine is n't the lone factor involved in good blood force per unit area control, it predicts that it is most likely the chief factor. ( SCHROEDER et al, 2004 ) It has been reported than in the USA merely thirty five per centum of patients who suffer from high blood pressure have achieved equal blood force per unit area control. Unfortunately, non-compliance is one of the main barriers to intervention of high blood pressure. Vaccines against high blood pressure, injected every 4 – 6 months, can to an extent combat non-compliance. ( DO et al, 2010 ) High blood pressure unfortunately remains uncontrolled in over 50 % of treated patients. Some of the barriers which prevent good high blood pressure control include those that are physician-related, patient centred and all those related to the wellness system. The designation of uncontrolled high blood pressure and immune high blood pressure require good attending to accurate blood force per unit area measuring. Awareness of lifestyle factors, secondary causes of high blood pressure and right intervention are all important to designation of uncontrolled high blood force per unit area and immune high blood pressure. ( WOFFORD et al, 2009 ) There was a really interesting paper published last twelvemonth which looked at aged patients and conformity to anti hypertensive medicines. It was shown that up to a 3rd of aged hypertensive patients do non adhere to their medicine. Attachment to these medicines lessenings with increasing age, and besides with diminishing cognitive ability. Therefore more aged patients who are besides cognitively-impaired have poorer control of their blood force per unit area. Good control of blood force per unit area has been associated with reduced prevalence of both Alzheimer ‘s disease and dementedness, hence it is imperative that this category of the population is carefully monitored with regard to conformity to medicine. ( GARD et al, 2010 ) Decision In decision, the intervention of high blood force per unit area is more or less based on both drug therapy and lifestyle intercessions. Both of these things require patient attachment to be effectual. Unfortunately hapless conformity is seen in both of these attacks ; this is the chief ground for deficient blood force per unit area control. ( SAMUELSSON et al, 2008 ) Electrical field stimulation of carotid fistula baroreflex sensory nerves will acutely diminish arterial blood force per unit area in some patients who have treatment-resistant arterial high blood pressure or who are antihypertensive drugs. The stimulation will go forth the existent baroreflex map undisturbed. ( HEUSSER et al, 2010 ) This surgically deep-rooted Rheos device ( which electrically stimulates the carotid baroreflex system ) can be placed safely in a patient and will bring forth rather a important acute lessening in blood force per unit area without any major side effects. ( ILLIG et al, 2006 ) The catheter-based nephritic sympathetic denervation in add-on to standard pharmacologic therapy has shown to diminish high blood force per unit area values by a high magnitude ; this is likely to be priceless in diminishing the hazards of shot, bosom failure, shot and chronic renal failure which are all major slayers in the United Kingdom. ( Katholi et al, 2009 ) If inoculation against high blood force per unit area was both safe and effectual in the hereafter, it would perchance work out many jobs of non-compliance and non attachment to medicine. The test published in 2008 in the Lancet was true rather little and the writers even say themselves that more big graduated table surveies need to be carried out in order to demo the safety and efficaciousness of antibodies against angiotonin II in patients with high blood force per unit area. However, the consequences of this new vaccinum are really promising, and inoculation for high blood pressure may turn out to be really positive in many patients. ( HERLITZ et al, 2008 ) In decision, the three new drug therapies that I have talked about all have great possible ; hopefully they will all go successful therapies for future intervention immune hypertensive patients.

Leonard Susskind - Theoretical Physicist

Leonard Susskind - Theoretical Physicist In 1962, Leonard Susskind earned a B.A. in physics from City College of New York after transitioning from his plan to get a degree in engineering. He earned his Ph.D. in 1965 from Cornell University. Dr. Susskind worked at Yeshiva University as an Associate Professor from 1966 to 1979, with a year at University of Tel Aviv from 1971 to 1972, before becoming a Professor of Physics at Stanford University in 1979, where he remains to this today. He was awarded the Felix Bloch Professorship of Physics since the year 2000. String Theory Insights Probably one of Dr. Susskinds most profound accomplishments is that hes credited as one of the three physicists who independently realized, back in the 1970s, that a certain mathematical formulation of particle physics interactions seemed to represent oscillating springs ... in other words, hes considered one of the fathers of string theory. He has done extensive work within string theory, including the development of a matrix-based model. Hes also responsible for one of the more recent discoveries in the exploration of theoretical physics, the holographic principle, which many, including Susskind himself, believe will provide great insights into how string theory applies to our universe. In addition, in 2003 Susskind coined the term string theory landscape to describe the set of all physically possible universes that could have come into being under our understanding of the laws of physics. (At present, this could contain as many as 10500 possible parallel universes.) Susskind is a strong proponent of applying reasoning based upon the anthropic principle as a valid means to evaluate which physical parameters its possible for our universe to have. Black Hole Information Problem One of the most troubling aspects of black holes is that when something falls into one, it is lost to the universe forever. In the terms that physicists use, information is lost ... and that isnt supposed to happen. When Stephen Hawking developed his theory that black holes actually radiated an energy known as Hawking radiation, he believed that this radiation would be insufficient to actually resolve the problem. The energy radiating out from the black hole under his theory would not contain enough information to fully describe all of the matter that fell into the black hole, in other words. Leonard Susskind disagreed with this analysis, believing quite strongly that the conservation of information was so important to the underlying foundations of quantum physics that it could not be violated by black holes. Ultimately, the work in black hole entropy and Susskinds own theoretical work in developing the holographic principle have helped to convince most physicists - including Hawking himself - that a black hole would, over the course of its lifetime, emit radiation that contained the full information about everything that ever fell into it. Thus most physicists now believe that no information is lost in black holes. Popularizing Theoretical Physics Over the last few years, Dr. Susskind has become more well-known among lay audiences as a popularizer of advanced theoretical physics topics. He has written the following popular books on theoretical physics: The Cosmic Landscape: String Theory and the Illusion of Intelligent Design (2005) - This book presents Susskinds view of how string theory predicts a vast string theory landscape and how the anthropic principle can be applied to evaluate the various physical properties of our universe against all of the assorted possibilities. This is described above in the string theory section.The Black Hole War: My Battle with Stephen Hawking to Make the World Safe for Quantum Mechanics (2008) - In this book, Susskind describes the black hole information problem (described above), framed as an intriguing narrative about a disagreement within the theoretical physics community ... one which has taken decades to resolve.The Theoretical Minimum: What You Need to Know to Start Doing Physics with George Hrabovsky (2013) - A math-based introduction to the fundamental concepts within classical mechanics, such as conservation of energy and symmetries in physical laws, which is intended to lay the groundwor k for what someone would need to know to proceed to the next level in physics. This is based on lectures that are available online, as described below. In addition to his books, Dr. Susskind has presented a series of lectures that are available online through both iTunes and YouTube ... and which provide the basis of The Theoretical Minimum. Here is a list of the lectures, in roughly the order that I would recommend viewing them, along with links to where you can view the videos for free: Classical Mechanics (YouTube) - A 10-lecture series focusing on the fundamentals of classical mechanicsThe Theoretical Minimum: Quantum Mechanics (YouTube) - A 10-lecture series that tries to understand what physicists know about quantum mechanicsSpecial Relativity (YouTube) - A 10-lecture series explaining Einsteins theory of special relativityGeneral Relativity (YouTube) - A 10-lecture series that lays out the modern theory of gravity: general relativityParticle Physics: Standard Model (YouTube) - A 9-lecture series focusing on the Standard Model of particle physicsCosmology (YouTube) - A 3-lecture series focusing on what we know and understand about the history and structure of our universeString Theory and M-Theory (YouTube) - A 10-lecture series focusing on the fundamentals of string theory and M-TheoryTopics in String Theory (YouTube) - A 9-lecture series focusing on the fundamentals of string theory and M-Theory As you may have noticed, some of the themes repeat between lecture series, such as the two different lecture sets on string theory, so you shouldnt need to watch them all if there are redundancies ... unless you really want to.

Structure of the UN essays

Structure of the UN essays The League of Nations was a world organization established in 1920 to promote international cooperation and peace. It was first proposed in 1918 by President Woodrow Wilson, although the United States never joined the League. The league was essentially powerless and it was officially dissolved in 1946. This former international organization was formed after World War I to promote international peace and security. The basis of the League, the Covenant, was written into the Treaty of Versailles and other peace treaties and provided for an assembly, a council, and a secretariat. A system of colonial mandates was also set up. The U.S., which failed to ratify the Treaty of Versailles, never became a member. Based in Geneva, the League proved useful in settling minor international disputes, but was unable to stop aggression by major powers. For example Japan's occupation of Manchuria (1931), Italy's conquest of Ethiopia (1935-36), and Germany's seizure of Austria (1938). It collapsed early in World War II and dissolved itself in 1946. The League established the first pattern of permanent international organization and served as a model for its successor, the United Nations. The UN an international organization composed of most of the countries of the world was founded in 1945 to promote peace, security, and economic development. This international organization was established immediately after World War II to maintain international peace and security and to achieve cooperation in solving international economic, social, cultural, and humanitarian problems. It replaced the League of Nations. The name was coined by President Franklin Delano Roosevelt in 1941 to describe the countries fighting against the Axis powers in World War II. It was first used officially on January 1, 1942 when 26 states joined in the Declaration by the United Nations, pledging to continue their joint war effort and to make peace. The UN Charter, the organ ...

Effect of the Population Growth Policy on the Economic Growth in Research Paper

Effect of the Population Growth Policy on the Economic Growth in France and Germany - Research Paper Example The increased birth rate is subject to numerous factors e.g. sociological, psychological, and cultural factors. The French government, using the family policy ensures the birthrate increases without having a big impact on the living standards. The infant mortality rate in France has fallen by 30 percent and this has led to an increased population. The population growth rate in France and Germany affect the prospects of economic growth directly. Population growth policy is a deliberately constructed institutional arrangement with specific programs through which governments influence the demographic change. The definition is vulnerable to multiple interpretations. It can also be viewed as a mechanism aimed at bringing qualitative changes into the populace of the territory under the government’s jurisdiction. The additions to membership are effected through births and immigration while losses are caused by death and emigration. The death rate is seen to fall, under health policy leaving the immigration and emigration to be subject to the governmental direction in population growth policy. This paper seeks to look into the effects of population growth on economic growth in France and Germany. The governments of France and Germany have been careful to allow modification of qualitative aspects of population growth policy. This has been tried to the family policy of both countries. The governments targeted the family unit as the most appropriate place to target growth. The policy looks into migration, fertility and the composition of these populations. This happens through the use of demographic factors and spatial distribution of the population. The birth rate in France is said to be falling. The lion share of the French national income goes to the family as opposed to other expenditure. The rising standard of living in France has altered the position of women in the society.

Managing health services for quality Essay Example | Topics and Well Written Essays - 3750 words

Managing health services for quality - Essay Example Nonetheless, a mere increase in the budget without the corresponding increase in the number of personnel does not result in a more efficient and competent service. Efficiency will only be enhanced by a small percentage due to the heightened motivation brought about by the increase in salary. It is emphasized that while the workforce has exhibited noticeable enthusiasm in its performance, this is not reflective of true efficiency since this will plateau after a period of time when effect of the budget or wage increase has lost its appeal or when fatigue sets in. Efficiency should not therefore be measured by the amount of money poured into the NHS as the amount of money does not create more time for the same number of personnel to perform their functions with efficiency and fervour. Efficiency therefore should be computed base on the number of patients handled per NHS personnel. Please note that NHS is not composed solely of medical personnel who actually interact with patients but ra ther it is also complemented by administrative personnel and other non-essential or semi-essential staff to run efficiently. Efficiency should similarly be equated on the number of essential personnel whose responsibility involves face to face interaction with patients. Focusing on Jo Webber’s letter regarding ambulance response time, Jo was in the opinion that essential to meeting response time for ambulance is also satisfying the actual need of the patient in such time of medical distress. It would not make any sense he averred that the ambulance is at the scene simply to meet the time limit but is inutile in responding to the medical needs of the patient. It cannot be ignored however that measuring response time is the only visible aspect of emergency response that can be considered to quantify efficiency. Other factors such as effectiveness of the team will always rely on the present situation since at most every ambulance is only equipped to respond to certain emergencie s but definitely not on all emergencies. Otherwise every ambulance will be considered a moving field hospital travelling in excess of 100kph on the average. Chris Week’s letter regarding patient empowerment elucidated the need for patient to choose the kind of medical care a person would like to have and from whom. Although NHS and some HMO guarantee the best kind of service available to residents, the extent of a patient’s empowerment should not go beyond what is required to fulfil the mandate of medical practitioners to provide medical care. To illustrate: There are patients who cannot decide rationally because of their fear as to the severity of their medical condition. Imposing patient empowerment on the situation would run counter to the interest of the patient and if it remains unabated notwithstanding benign illnesses, patients would demand the performance of unnecessary tests simply to convince them of a non-existent syndrome in the first place to the detriment of those patients who are in dire need treatment. b. Cause: Regarding Richard Barnes comment: NAO’s concern although fiscal competence should also take into consideration the fiscal cost of efficiency. Fiscal cost of efficiency refers to the amount of capital needed to achieve a certain level of efficiency. In this case, it would seem that there is confusion with regards to the efficiency criteria NAO is trying to project to the public. Measuring efficiency based on the